Buy HepcDac 60 mg (Daclatasvir) Online
Buy HepcDac 60 mg (Daclatasvir) Online, Daclatasvir is one of the new direct-acting antiviral drugs that target different steps of the hepatitis C virus (HCV) lifecycle. HepcDac is used to treat genotype 1 and genotype 3 chronic hepatitis C in adults with or without cirrhosis.HepcDac is given together with another drug called Sovaldi (sofosbuvir).
Pharmacology
Pharmacodynamics
Mechanism of Action
Daclatasvir is a direct-acting antiviral (DAA) against the hepatitis C virus (HCV). Daclatasvir is an inhibitor of HCV nonstructural protein 5A (NS5A).
Cardiac Electrophysiology
At a dose 3 times the maximum recommended dose, daclatasvir does not prolong the QT interval to any clinically relevant extent.
Pharmacokinetics
The pharmacokinetic properties of daclatasvir were evaluated in healthy adult subjects and in subjects with chronic HCV. Administration of daclatasvir tablets in HCV-infected subjects resulted in approximately dose-proportional increases in Cmax, AUC, and Cmin up to 60 mg once daily. Steady state is anticipated after approximately 4 days of once-daily daclatasvir administration. Exposure of daclatasvir was similar between healthy and HCV-infected subjects.
How does HepcDac work?
Daclatasvir prevents RNA replication and virion assembly by binding to NS5A, a nonstructural phosphoprotein encoded by HCV. Binding to the N-terminus of the D1 domain of NS5A prevents its interaction with host cell proteins and membranes required for virion replication complex assembly.
Daclatasvir must be used in combination with other medicines that attack the hepatitis C virus in different ways. If daclatasvir is used on its own there is a high chance that the hepatitis C virus will become resistant to it.
Special Populations
Gender
Population pharmacokinetic analyses in HCV-infected subjects estimated that female subjects have a 30% higher daclatasvir AUC compared to male subjects. This difference in daclatasvir AUC is not considered clinically relevant.
Race
Population pharmacokinetic analyses in HCV-infected subjects indicated that race had no clinically relevant effect on daclatasvir exposure.
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