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Buy Hepcvel (Generic Sofosbuvir and velpatasvir), Hepcvel contains a combination of sofosbuvir and velpatasvir. Sofosbuvir and velpatasvir are antiviral medications that prevent hepatitis C virus (HCV) from multiplying in your body. Hepcvel is used to treat chronic hepatitis C in adults with HCV genotype 1, 2, 3, 4, 5, or 6. Hepcvel (Generic Sofosbuvir and velpatasvir) is given in combination with another antiviral medicine called ribavirin in people who also have advanced cirrhosis.

How should I take Hepcvel (Generic sofosbuvir and velpatasvir)?

Hepcvel (Generic sofosbuvir and velpatasvir) is usually taken once per day for 12 weeks. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. You may take Hepcvel (Generic sofosbuvir and velpatasvir) with or without food. Read the medication guide or patient instructions provided with each medication you take.

Do not change your doses or medication schedule without your doctor’s advice. Every person with hepatitis C should remain under the care of a doctor. While using Hepcvel (Generic sofosbuvir and velpatasvir), you may need frequent blood tests. Store this medicine in the original container at room temperature away from moisture and heat.

Hepcvel (Generic Sofosbuvir and Velpatasvir) side effects

Side effects that you should report to your doctor or health care professional as soon as possible: -allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue -breathing problems -depressed mood -dizziness -unusually weak or tired Side effects that usually do not require medical attention (Report these to your doctor or health care professional if they continue or are bothersome.): -diarrhea -headache -irritable -nausea -tiredness -trouble sleeping

Where should I keep my medicine?

Keep out of the reach of children. Store at room temperature below 30 degrees C (86 degrees F). Throw away any unused medicine after the expiration date. NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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MyHep contains the active ingredient Sofosbuvir. It is a generic brand of anti-viral medication used to treat Hepatitis C virus. MyHep is manufactured by Mylan Pharmaceuticals. Sofosbuvir can help the immune system and the liver recover from an Hepatitis C infection.

What is ethambutol?

Ethambutol is an antibiotic that prevents growth of the tuberculous bacteria in the body. Ethambutol is used to treat tuberculosis (TB), and is usually given together with at least one other tuberculosis medicine. Ethambutol may also be used for purposes not listed in this medication guide.

What is the most important information I should know about ethambutol?

Ethambutol can cause serious vision problems or irreversible vision loss. You may not be able to take this medicine if you have an eye problem or vision disorder.

Uses

MyHep (Sofosbuvir) is mostly prescribed for the treatment of Hepatitis C and can treat genotypes 1, 2, 3, and 4 of Hepatitis C. It is to be taken along with other medications in combination. These other medications are usually ribavirin (for all four genotypes) and pegylated interferon (for genotypes 1 and 4).

Dosage and Administration

MyHep (Sofosbuvir) will be prescribed for a period of 12 weeks in most cases for genotypes 1,2 and 3. For genotype 4 the treatment period is usually 24 weeks. You may be instructed differently by your doctor and should follow their advice as these are only guidelines. If you are taking ribavirin and/or pegylated interferon, these should be taken for the same length of time. It is advised to take the medicines at the same time, and to do so at the same time each day. If you take MyHep in the morning it can help to reduce associated sleeping disorders, and if you take it with food it can help reduce nausea.

Sofosbuvir is usually prescribed at a dosage of 400mg. Depending on your weight, the genotype of Hepatitis C Virus that has been contracted, and other factors determined by your doctor, you may be prescribed a different dosage. Only take the dosage that has been prescribed by your doctor. Dosage could be increased to 600 mg per day depending on how treatment is progressing. Do not adjust the dosage by yourself. Your doctor will advise you if you need to adjust your dosage based on testing.

Side effects

MyHep (Sofosbuvir) is well tolerated by the majority of people. It is common to experience some nausea and insomnia, especially when starting to take sufosbuvir. You can reduce the severity of these side effects by taking MyHep with food (for nausea) and taking your dose in the morning (for insomnia).

Sofosbuvir could reduce your red blood cell count. Regular blood tests can ensure that these levels remain within normal limits.
Liver function can be affected by taking MyHep (Sofosbuvir). Any patients with a history of pre-existing liver problems should not use this Sofosbuvir. Liver function tests should be taken on a regular basis while treating Hepatitis C with Sofosbuvir.

If you experience severe diarrhea, changes to heart rate or breathing difficulties while taking sofosbuvir, let your doctor know immediately.

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Hepcvir 400 mg Tablet is an antiviral medicine used in the treatment of chronic hepatitis C infection. It is also used in patients with liver cancer and hepatitis C infection who are planning to have a liver transplantation. This medicine minimizes the chance of recurrence of the infection after the transplantation. Hepcvir 400 mg Tablet is not recommended for use in patients with a known history of hepatitis B infection.

How MyHep LVIR (Ledipasvir and Sofosbuvir) Works?

• Ledipasvir inhibits the HCV NS5A protein, which is required for viral replication.
• Sofosbuvir inhibits HCV NS5B RNA-dependent RNA polymerase, which is required for viral replication.

Uses

Hepcvir (Sofosbuvir) used to treat chronic Hepatitis C (HCV) infection. The medicine has given a higher cue rates and fewer side effects, reported 96.4% of patient had complete recovery.
This medication is safe for taking one table in daily with combination therapy. It allows most patient to be treat successfully with less side effects. The combination of other prescribed medicines Ribavirin to treat HCV genotypes 2 and 3 or triple therapy with injection Peginterferon Alfa medicine to treat HCV genotypes 1 and 4.
Sofosbuvir is also can be used in HCV patients with an HIV coinfection and safe to use with patient who is waiting for liver transplant.

Dosage and Administration

Sofosbuvir can be take 1 tablet a day before or after meal around the same time every day. You may to use at appropriate amount by instructing from your doctor. This medication is taken in combination with pegylated interferon and ribavirin, or with ribavirin alone, it usually taken for 12-24 weeks.
If you have liver cancer and are waiting for a liver transplant, you will take sofosbuvir with ribavirin for up to 48 weeks or until you have a liver transplant. The length of your treatment depends on your condition, how well you respond to the medication, and whether you experience severe side effects.
For the professional advice of different combination on therapy, please see advice from your health care or professional doctor.

Side effects

Here is a list of most common side effects by taking Hepcvir (Sofosbuvir):

• Diarrhea
• Nausea
• Headache
• Muscle Pain
• Loss of appetite
• Sleeping difficultly
• Dizziness
• Depress

Some side effect can be serious. If you have unusual experience and problems, you should contact your doctors or Healthcare right immediately.



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Myhep LVIR (Ledipasvir and sofosbuvir) is used for

Treating chronic hepatitis C virus (HCV) infection in certain patients.

Ledipasvir and sofosbuvir is a combination of 2 hepatitis C virus (HCV) antiviral agents. It reduces the amount of HCV in the body by preventing the spread of the HCV within the body.

Uses

MyHep LVIR is a prescription medicine used with or without ribavirin for the treatment of chronic (lasting a long time)  (HCV) genotype 1, 4, 5 or 6 infection.

What is MyHep LVIR (Ledipasvir and Sofosbuvir)?

MyHep LVIR is a fixed-dose combination tablet containing ledipasvir and sofosbuvir for oral administration. Ledipasvir is an HCV NS5A inhibitor and sofosbuvir is a nucleotide analog inhibitor of HCV NS5B polymerase. Each tablet contains ledipasvir 90 mg and sofosbuvir 400 mg.

How MyHep LVIR (Ledipasvir and Sofosbuvir) Works?

• Ledipasvir inhibits the HCV NS5A protein, which is required for viral replication.
• Sofosbuvir inhibits HCV NS5B RNA-dependent RNA polymerase, which is required for viral replication.

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Hepcinat LP is a fixed-dose combination tablet containing Ledipasvir 90mg and Sofosbuvir 400 mg for oral administration used with or without ribavirin for the treatment of chronic (lasting a long time) hepatitis C virus (HCV) genotype 1, 4, 5 or 6 infection.

 

Hepcvir L (Ledipasvir and sofosbuvir) is used for

Treating chronic hepatitis C virus (HCV) infection in certain patients.

Ledipasvir and sofosbuvir is a combination of 2 hepatitis C virus (HCV) antiviral agents. It reduces the amount of HCV in the body by preventing the spread of the HCV within the body.

How to use Hepcvir L (ledipasvir and sofosbuvir)

Use ledipasvir and sofosbuvir as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with ledipasvir and sofosbuvir. Talk to your pharmacist if you have questions about this information.
• Take ledipasvir and sofosbuvir by mouth with or without food.
• Do not take an antacid that has aluminum or magnesium in it within 4 hours of ledipasvir and sofosbuvir.
• If you take cimetidine, dexlansoprazole, esomeprazole, famotidine, lansoprazole, nizatidine, omeprazole, pantoprazole, rabeprazole, or ranitidine, ask your doctor or pharmacist how to take it with ledipasvir and sofosbuvir.
• Ledipasvir and sofosbuvir works best if it is taken at the same time each day.

Effect of Food

Relative to fasting conditions, the administration of a single dose of ledipasvir -sofosbuvir FDC with a moderate fat (~600 kcal, 25% to 30% fat) or high fat (~1,000 kcal, 50% fat) meal increased sofosbuvir AUC_0-inf by approximately 2-fold, but did not significantly affect sofosbuvir C_max. The exposures of GS-331007 and ledipasvir were not altered in the presence of either meal type. The response rates in Phase 3 trials were similar in HCV-infected subjects who received ledipasvir - sofosbuvir FDC with food or without food. Ledipasvir-sofosbuvir FDC can be administered without regard to food.    

Side effects Of Hepcinat LP (Ledipasvir and Sofosbuvir)

Hepcinat LP’s active ingredients are ledipasvir & sofosbuvir which may have reported side effects as under:

common side effects / symptoms – consult your doctor or medical practitioner if you experience any common side effects or symptoms such as nausea, diarrhea, headache, loss of appetite, lower back pain, side pain, insomnia (sleeplessness) and/or fever.

serious side effects / symptoms – discontinue use of Hepcinat LP and contact your emergency medical center right away if you experience any signs of pale skin, hives, rashes, edema (swelling), mood changes, excessive fatigue, behavior changes, irregular heartbeat, breathing difficulty, breathlessness, swallowing difficulty and/or signs of any infection.

unknown side effects / symptoms – Hepcinat LP may cause other unknown side effects or symptoms not listed here. For complete information, discuss the use of Hepcinat LP with your doctor or healthcare medical practitioner before use.

How should I store Hepcinat LP?

• Store Hepcinat LP at room temperature below 86° F (30° C).

• Keep Hepcinat LP in its original container.

• Do not use Hepcinat LP if the seal over the bottle opening is broken or missing.

• Keep Hepcinat LP and all medicines out of the reach of children.

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Buy Sofosbuvir and Daclatasvir online, Daclatasvir–sofosbuvir combination therapy with or without ribavirin for hepatitis C virus infection: from the clinical trials to real life, Daclatasvir plus sofosbuvir works well for people with genotype 3 hepatitis C and advanced liver disease in real-world clinical practice.

Abstract

The treatment of hepatitis C virus has changed dramatically with the rapid advent of numerous new antiviral agents, including direct-acting antivirals and agents with non-viral targets (cyclophilin inhibitors, interferon-lambda, vaccine therapy). Given the better safety profile and high antiviral potency of direct-acting antivirals, their combination in interferon-free oral regimens is becoming the standard of care for hepatitis C virus infection, tailored to individual patients according to the degree of disease progression (fibrosis), hepatitis C virus genotype and subtype, resistance profile, and prior therapeutic history.

Results from clinical studies as well as preliminary real-life data regarding the combination of sofosbuvir (a nucleotide polymerase inhibitor) and daclatasvir, a first-in-class NS5A replication complex inhibitor, demonstrate that it is one of the most promising antiviral therapies, with once-daily oral dosing, a low pill burden, good tolerability, and limited drug–drug interactions, in addition to high antiviral potency, with >90% sustained virologic response rates. This combination has high pangenotypic antiviral potency regardless of the severity and patient characteristics. The combination of sofosbuvir and an NS5A inhibitor with ribavirin for 12 weeks appears to be a very good further treatment option in both cirrhotic and treatment-experienced patients whatever the stage of fibrosis.

Side effects

• ChillsSEVERE
• Ulcers or white spots in the mouthSEVERE
• Lower back painSEVERE
• HeadacheSEVERE
• RashSEVERE
• IrritabilitySEVERE
• Diarrhea
• Nausea
• Decreased appetite
• Muscle pain and cramp

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Buy HepcDac 60 mg (Daclatasvir) Online, Daclatasvir is one of the new direct-acting antiviral drugs that target different steps of the hepatitis C virus (HCV) lifecycle. HepcDac is used to treat genotype 1 and genotype 3 chronic hepatitis C in adults with or without cirrhosis.HepcDac is given together with another drug called Sovaldi (sofosbuvir).

Pharmacology

Pharmacodynamics

Mechanism of Action

Daclatasvir is a direct-acting antiviral (DAA) against the hepatitis C virus (HCV). Daclatasvir is an inhibitor of HCV nonstructural protein 5A (NS5A).

Cardiac Electrophysiology

At a dose 3 times the maximum recommended dose, daclatasvir does not prolong the QT interval to any clinically relevant extent.

Pharmacokinetics

The pharmacokinetic properties of daclatasvir were evaluated in healthy adult subjects and in subjects with chronic HCV. Administration of daclatasvir tablets in HCV-infected subjects resulted in approximately dose-proportional increases in C_max, AUC, and C_min up to 60 mg once daily. Steady state is anticipated after approximately 4 days of once-daily daclatasvir administration. Exposure of daclatasvir was similar between healthy and HCV-infected subjects.

How does HepcDac work?

Daclatasvir prevents RNA replication and virion assembly by binding to NS5A, a nonstructural phosphoprotein encoded by HCV. Binding to the N-terminus of the D1 domain of NS5A prevents its interaction with host cell proteins and membranes required for virion replication complex assembly.

Daclatasvir must be used in combination with other medicines that attack the hepatitis C virus in different ways. If daclatasvir is used on its own there is a high chance that the hepatitis C virus will become resistant to it.

Special Populations

Gender

Population pharmacokinetic analyses in HCV-infected subjects estimated that female subjects have a 30% higher daclatasvir AUC compared to male subjects. This difference in daclatasvir AUC is not considered clinically relevant.

Race

Population pharmacokinetic analyses in HCV-infected subjects indicated that race had no clinically relevant effect on daclatasvir exposure.

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MyDekla ( Daclatasvir) is specifically indicated for use with sofosbuvir for the treatment of patients with chronic hepatitis C virus (HCV) of genotype 1, 3, or 4 infections. The other medications used in combination include sofosbuvir, ribavirin, and interferon, vary depending on the virus type and whether the person has cirrhosis.

MyDekla ( Daclatasvir) stops HCV viral RNA replication and protein translation by directly inhibiting HCV protein NS5A. NS5A is critical for HCV viral transcription and translation,

MyDekla ( Daclatasvir)is supplied as tablets for oral administration. It is taken by mouth once a day. The recommended dose is 60 mg taken orally once daily with or without food in combination with sofosbuvir. The recommended treatment duration is 12 weeks. Dose modification: reduce dosage to 30 mg once daily with strong CYP3A inhibitors and increase dosage to 90 mg once daily with moderate CYP3A inducers. 

Mechanism of Action

Daclatasvir When Used In Combination Treatment With Sofosbuvir May Result In Slowing Of The Heart Rate (Pulse) Along With Other Symptoms When Taken With Amiodarone, A Medicine Used To Treat Certain Heart Problems.

Daclatasvir Is a Direct-Acting Antiviral Agent (DAA) Against the Hepatitis C Virus.

Side effects

Tiredness, headache, nausea, or diarrhea may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

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Lamivir 100 mg Tablet is an antiviral medicine which is used to treat human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections. This medicine is not a cure for HIV. It only prevents the virus from multiplying in your body. Monitoring of liver function and kidney function may be necessary while receiving this medicine based on the clinical condition.

Uses

Lamivudine indicated as part of antiretroviral combination therapy for the treatment of Human Immunodeficiency Virus (HIV) infected adults and children and also used in the treatment of Hepatitis B virus infection.

How it works

Lamivudine belongs to a class of medication called nucleoside reverse transcriptase inhibitors. It decreases the amount of virus (HIV and hepatitis) in the blood. It also increases the number of infection fighting cells in the body (CD4 cells). It does not cure HIV completely but reduces the chances of getting acquired immunodeficiency syndrome (AIDS) and HIV related infections or cancer.

Common side effects

runny nose; rash or hair loss; fever; insomnia ., indigestion, nausea, diarrhea; cough, dizzy or tired; rash, joint pain, itching; hair loss; headache, stomach pain, muscle pain or discomfort; vomiting, Feeling weak

• Chills and feverSEVERE
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• HeadacheSEVERE
• FatigueSEVERE
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• Stuffy nose
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• Indigestion
• Sore throat

Expert advice

• Consult your doctor if you have diabetes and are using insulin.
• Patients receiving this therapy are always at a risk for infections and hence should report any such cases to the doctor.
• Consult your doctor if you take any prescription medication; Inform your doctor if you take other medicine for treatment of HIV or hepatitis B infection, hairy cell leukemia [a type of blood cancer], or antibiotics for infection.
• Lamivudine may rarely cause a serious side effect like lactic acidosis with symptoms such as pain or weakness of muscle, numbness or feeling cold in arms or legs, stomach pain, nausea, vomiting, lack of breath, aberrant heart rate, dizziness, weak or tired feeling; hence, inform the doctor immediately if you experience any of these symptoms.

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Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an relevant role in viral replication, assembly, and secretion. Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase—the key enzyme mediating HCV RNA replication. The triphosphate form of sofosbuvir (GS-461203) mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the enlarging RNA primer strand, resulting in viral chain termination.

COMMON SIDE EFFECTS

• Ledipasvir and sofosbuvir may cause some side effects. Tell your doctor if any of these symptoms are severe or do not go away :
• Extreme tiredness; Unusual weakness or lack of energy; Confusion or memory problems; Slowed breathing;
• Headache; Chest pain, slow heartbeats, weak pulse; Diarrhea etc.

Not all side effects are listed above. However, you should always inform your health care provider if you experience any unusual side-effects

WARNING & PRECAUTIONS

Ledipasvir and sofosbuvir is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not use this medication without consult with your pharmacist, if you have :

• severe kidney disease;
• a hemoglobin blood cell disorder such as sickle-cell anemia or thalassemia etc.
• kidney disease
• liver problems other than hepatitis C etc.
• While using Ledifos Hepatitis medicine, you may need frequent blood tests.
• Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
• Continue to take Ledifos even if you feel well. The length of your treatment depends on your condition, how well you respond to the medication, and whether you experience severe side effects.
• Do not stop taking this medicine without talking to your pharmacist.Do not take this medication if you are allergic to Ledipasvir & Sofosbuvir or any ingredients of the medication.
• Tell your doctor or dentist that you take LedifosHepatitis Medicine before you receive any medical or dental care, emergency care, or surgery.
• If you take too much amount of this Hepatitis medicine, call your healthcare provider or go to the nearest hospital emergency room right away.

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